It was first suggested that the ribosome is associated with protein synthesis in the 1950s. Initially, its components were revealed as surface‐accessible proteins and as molecules of RNA apparently providing a scaffold for subunit shape. Attributing function to the proteins proved difficult, although bacterial protein L11 proved essential for binding one of the decoding protein release factors (RFs). With the discovery that RNA could be a catalyst, interest focussed on the rRNA that, in partnership with mRNA and tRNAs, could potentially (...) mediate the chemical reaction underlying protein synthesis. rRNA interactions and conformational changes were invoked as key elements that facilitated function. The decoding RFs, which are proteins, are exceptions to this rule because they usurp a tRNA function in mediating stop signal recognition. Cryoelectron microscopy and associated image reconstruction technology have now given dramatic snapshots of almost every step of protein synthesis, and X‐ray crystallography has revealed, at last, the subunits and monomeric ribosome in exquisite atomic detail. BioEssays 26:582–588, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Th is paper investigates the epistemic powers of democratic institutions through an assessment of three epistemic models of democracy : the Condorcet Jury Th eorem, the Diversity Trumps Ability Th eorem, and Dewey's experimentalist model. Dewey's model is superior to the others in its ability to model the epistemic functions of three constitutive features of democracy : the epistemic diversity of participants, the interaction of voting with discussion, and feedback mechanisms such as periodic elections and protests. It views democracy as (...) an institution for pooling widely distributed information about problems and policies of public interest by engaging the participation of epistemically diverse knowers. Democratic norms of free discourse, dissent, feedback, and accountability function to ensure collective, experimentallybased learning from the diverse experiences of diff erent knowers. I illustrate these points with a case study of community forestry groups in South Asia, whose epistemic powers have been hobbled by their suppression of women's participation. (shrink)

This paper investigates the epistemic powers of democratic institutions through an assessment of three epistemic models of democracy: the Condorcet Jury Theorem, the Diversity Trumps Ability Theorem, and Dewey's experimentalist model. Dewey's model is superior to the others in its ability to model the epistemic functions of three constitutive features of democracy: the epistemic diversity of participants, the interaction of voting with discussion, and feedback mechanisms such as periodic elections and protests. It views democracy as an institution for pooling widely (...) distributed information about problems and policies of public interest by engaging the participation of epistemically diverse knowers. Democratic norms of free discourse, dissent, feedback, and accountability function to ensure collective, experimentally-based learning from the diverse experiences of different knowers. I illustrate these points with a case study of community forestry groups in South Asia, whose epistemic powers have been hobbled by their suppression of women's participation. (shrink)

Fundamental problems of environmental sustainability, including climate change and fisheries management, require collective action on a scale that transcends the political and cultural boundaries of the nation-state. Rational, self-interested neoclassical economic theories of human behavior predict tragedy in the absence of third party enforcement of agreements and practical difficulties that prevent privatization. Evolutionary biology offers a theory of cooperation, but more often than not in a context of discrimination against other groups. That is, in-group boundaries are necessarily defined by those (...) excluded as members of out-groups. However, in some settings human’s exhibit behavior that is inconsistent with both rational economic and group driven cooperation of evolutionary biological theory. This paper reports the results of a non-cooperative game-theoretic exercise that models a tragedy of the commons problem in which groups of players may advance their own positions only at the expense of other groups. Students enrolled from multiple universities and assigned to different multi-university identity groups participated in experiments that repeatedly resulted in cooperative outcomes despite intergroup conflicts and expressions of group identity. We offer three possible explanations: students were cooperative because they were in an academic setting; students may have viewed their instructors as the out-group; or the emergence of a small number of influential, ethical leaders is sufficient to ensure cooperation amongst the larger groups. From our data and analysis, we draw out lessons that may help to inform approaches for institutional design and policy negotiations, particularly in climate change management. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Buddha through Christian EyesElizabeth J. HarrisIt was in Sri Lanka in 1984 that I had my first ‘encounter’ with the Buddha. When at the ancient city of Anuradhapura, I stole away from the group I was with to return for a few minutes to the shrine room adjacent to the sacred bo tree, the one believed to have grown from a cutting of the original tree under which (...) the Buddha gained enlightenment. Devotees dressed in white were sitting or prostrating silently. I joined them and looked toward the image, which showed the Buddha sitting in meditation against a painted scene of pale blue sky, white clouds, and mountains. Suddenly the image became more than mere plaster. All I can say is that it communicated. It beckoned. Against the blue of the sky, the serene head became suffused with cosmic significance. I know that there was unfinished business between me and the Buddha.The moment was prophetic. Two years later, I returned to Sri Lanka to study Buddhism and stayed over seven years. ‘Study’ is not quite the right word because, together with the academic, I also sought to immerse myself in Buddhism with the wish to see it through the eyes of Buddhists. I practiced meditation under Buddhist teachers, participated in temple devotion, and joined pilgrimages. It was a process that meant temporarily letting go of much that was dear to me as a Christian. But the rewards were inestimable. Never again has the image at Anuradhapura ‘spoken’ to me. In fact, on return visits it has appeared artistically poor, certainly no match for the older stone images, open to the air, in other parts of the city. But then, around and inside that very shrine room in May 1985, Tamil guerrillas gunned down 146 innocent devotees, rupturing centuries of devotion with pools of blood.My seven and a half years in Sri Lanka make it almost impossible for me to write about the Buddha as a complete outsider. I remain a Christian, but the Buddha has become part of me. An exquisitely carved wooden image of the Buddha in meditation is now part of my home. The peace that emanates from it gives me strength. In complete honesty, I can say that I revere the Buddha.But what Buddha do I revere? Do I revere the Buddha in the same way as Buddhists? To reflect on how my appreciation of the Buddha may be different from that [End Page 101] of Buddhists is not easy, for Buddhism contains within itself so many faces of the Buddha. There is the historical Buddha of the earlier parts of the Pali canon, the Buddha of the later hagiographic biographies, the Buddha of popular devotion, Mahayana Buddhism’s vision of multiple Buddhas and cosmic buddhahood, the Buddha of what has been termed Protestant Buddhism. Yet I sense that there is a common thread within all of these faces—namely, the Lord Buddha as the supreme embodiment of compassion and wisdom, the one who has seen into the nature of reality and the human predicament and has taught the path of liberation.All that I know of Buddhism tells me that the person of the Buddha is central. The devotion shown to the image is more than would be given to a human teacher and more than would be given to a god. Acchariya manussa is one phrase used in the Pali texts—“wonderful man.” He is human, yet more than human in that he was enlightened and worked toward this enlightenment without outside aid through countless lives of self-sacrifice and virtue. This I believe all Buddhists would agree to, and such a being is supremely worthy of reverence.How does my appreciation tally with this? It is the Theravada tradition that has nurtured my own understanding, and it has done so in three ways. First, there has been my reading of the Sutta Pitaka of the Pali canon. In the first two years of my time in Sri Lanka, I read through most of the nikaya of the Sutta Pitaka, albeit in translation, and I found myself encountering again and again a teacher I could respect and revere. “How... (shrink)

Due to constraints on institutional capacity and financial resources, the road to universal health coverage (UHC) involves difficult policy choices. To assist with these choices, scholars and policy makers have done extensive work on criteria to assess the substantive fairness of health financing policies: their impact on the distribution of rights, duties, benefits and burdens on the path towards UHC. However, less attention has been paid to the procedural fairness of health financing decisions. The Accountability for Reasonableness Framework (A4R), which (...) is widely applied to assess procedural fairness, has primarily been used in priority-setting for purchasing decisions, with revenue mobilization and pooling receiving limited attention. Furthermore, the sufficiency of the A4R framework’s four criteria (publicity, relevance, revisions and appeals, and enforcement) has been questioned. Moreover, research in political theory and public administration (including deliberative democracy), public finance, environmental management, psychology, and health financing has examined the key features of procedural fairness, but these insights have not been synthesized into a comprehensive set of criteria for fair decision-making processes in health financing. A systematic study of how these criteria have been applied in decision-making situations related to health financing and in other areas is also lacking. This paper addresses these gaps through a scoping review. It argues that the literature across many disciplines can be synthesized into 10 core criteria with common philosophical foundations. These go beyond A4R and encompass equality, impartiality, consistency over time, reason-giving, transparency, accuracy of information, participation, inclusiveness, revisability and enforcement. These criteria can be used to evaluate and guide decision-making processes for financing UHC across different country income levels and health financing arrangements. The review also presents examples of how these criteria have been applied to decisions in health financing and other sectors. (shrink)

The Doris Duke Charitable Foundation's competitive career development award selects awardees annually. This paper describes changes DDCF made to its grants making process to improve gender representation in its applicant and awardee pools.

What is the proper role of politics in higher education? Many policies and reforms in the academy, from affirmative action and a multicultural curriculum to racial and sexual harassment codes and movements to change pedagogical styles, seek justice for oppressed groups in society. They understand justice to require a comprehensive equality of membership: individuals belonging to different groups should have equal access to educational opportunities; their interests and cultures should be taken equally seriously as worthy subjects of study, their persons (...) treated with equal respect and concern in communicative interaction. Conservative critics of these egalitarian movements represent them as dangerous political meddling into the disinterested pursuit of knowledge. They cast the pursuit of equality as a threat to freedom of speech and academic standards. In response, some radical advocates of such programs agree that the quest for equality clashes with free speech, but view this as an argument for sacrificing freedom of speech. (shrink)

Of other ancient writers, call into question the traditional view that katharsis in the Poetics is a homeopathic process - one in which pity and fear affect emotions like themselves. She maintains, instead, that Aristotle considered katharsis to be an allopathic process in which pity and fear purge the soul of shameless, antisocial, and aggressive emotions. While exploring katharsis, Tragic Pleasures analyzes the closely related question of how the Poetics treats the.

Despite increasing interest in the figure of Socrates and in love in ancient Greece, no recent monograph studies these topics in all four of Plato's dialogues on love and friendship. This book provides important new insights into these subjects by examining Plato's characterization of Socrates in Symposium, Phaedrus, Lysis and the often neglected Alcibiades I. It focuses on the specific ways in which the philosopher searches for wisdom together with his young interlocutors, using an art that is 'erotic', not in (...) a narrowly sexual sense, but because it shares characteristics attributed to the daimon Eros in Symposium. In all four dialogues, Socrates' art enables him, like Eros, to search for the beauty and wisdom he recognizes that he lacks and to help others seek these same objects of erôs. Belfiore examines the dialogues as both philosophical and dramatic works, and considers many connections with Greek culture, including poetry and theater. (shrink)

In _On Paradox_ literary and legal scholar Elizabeth S. Anker contends that faith in the logic of paradox has been the cornerstone of left intellectualism since the second half of the twentieth century. She attributes the ubiquity of paradox in the humanities to its appeal as an incisive tool for exposing and dismantling hierarchies. Tracing the ascent of paradox in theories of modernity, in rights discourse, in the history of literary criticism and the linguistic turn, and in the transformation (...) of the liberal arts in higher education, Anker suggests that paradox not only generates the very exclusions it critiques but also creates a disempowering haze of indecision. She shows that reasoning through paradox has become deeply problematic: it engrains a startling homogeneity of thought while undercutting the commitment to social justice that remains a guiding imperative of theory. Rather than calling for a wholesale abandonment of such reasoning, Anker argues for an expanded, diversified theory toolkit that can help theorists escape the seductions and traps of paradox. (shrink)

Research on human infants has begun to shed light on early-developing processes for segmenting perceptual arrays into objects. Infants appear to perceive objects by analyzing three-dimensional surface arrangements and motions. Their perception does not accord with a general tendency to maximize figural goodness or to attend to nonaccidental geometric relations in visual arrays. Object perception does accord with principles governing the motions of material bodies: Infants divide perceptual arrays into units that move as connected wholes, that move separately from one (...) another, that tend to maintain their size and shape over motion, and that tend to act upon each other only on contact. These findings suggest that o general representation of object unity and boundaries is interposed between representations of surfaces and representations of objects of familiar kinds. The processes that construct this representation may be related to processes of physical reasoning. (shrink)

Most naturalists think that the belief/desire model from Hume is the best framework for making sense of motivation. As Smith has argued, given that the cognitive state (belief) and the conative state (desire) are separate on this model, if a moral judgment is cognitive, it could not also be motivating by itself. So, it looks as though Hume and Humeans cannot hold that moral judgments are states of belief (moral cognitivism) and internally motivating (moral internalism). My chief claim is that (...) the details of Hume’s naturalistic philosophy of mind actually allow for a conjunction of these allegedly incompatible views. This thesis is significant, since readers typically have thought that Hume’s view that motivation is not produced by representations, coupled with his view that moral judgments motivate on their own, imply that moral judgments could never take the form of beliefs about, or representations of, the moral (virtue and vice). (shrink)

Complex cognitive skills such as reading and calculation and complex cognitive achievements such as formal science and mathematics may depend on a set of building block systems that emerge early in human ontogeny and phylogeny. These core knowledge systems show characteristic limits of domain and task specificity: Each serves to represent a particular class of entities for a particular set of purposes. By combining representations from these systems, however human cognition may achieve extraordinary flexibility. Studies of cognition in human infants (...) and in nonhuman primates therefore may contribute to understanding unique features of human knowledge. 2020 APA, all rights reserved). (shrink)

Jonathan Dancy charges that Hutcheson's distinction between justifying reasons and motivating reasons is unimportant: it is simply between moral reasons and other good reasons. I argue that the distinction is between propositions with different presuppositions and different functions. One identifies qualities of objects that we desire; the other identifies qualities that we approve. I situate Hutcheson in the current debate about the nature of practical reasons. I argue that he avoids problems posed for factivists and for Humeans. On Hutcheson's view, (...) motivating and justifying reasons at times refer to the same qualities, which makes it possible for one to serve the function of the other. (shrink)

The importance of ethical listening -- The power of difference and values that unite -- Take off your armor and bring down the walls: adopting a listening posture -- Dolls and cages: listening as investment and care -- Deep listening: remembering and responding with intentional focus -- Hyenas and chickens: listening as invitation -- Hope for sustainable hospitality -- References -- About the author.

Experiments with young infants provide evidence for early-developing capacities to represent physical objects and to reason about object motion. Early physical reasoning accords with 2 constraints at the center of mature physical conceptions: continuity and solidity. It fails to accord with 2 constraints that may be peripheral to mature conceptions: gravity and inertia. These experiments suggest that cognition develops concurrently with perception and action and that development leads to the enrichment of conceptions around an unchanging core. The experiments challenge claims (...) that cognition develops on a foundation of perceptual or motor experience, that initial conceptions are inappropriate to the world, and that initial conceptions are abandoned or radically.. (shrink)

A new method was devised to test object permanence in young infants. Fivemonth-old infants were habituated to a screen that moved back and forth through a 180-degree arc, in the manner of a drawbridge. After infants reached habituation, a box was centered behind the screen. Infants were shown two test events: a possible event and an impossible event. In the possible event, the screen stopped when it reached the occluded box; in the impossible event, the screen moved through the space (...) occupied by the box. The results indicated that infants looked reliably longer at the impossible than at the possible event. This hnding suggested that infants (1) understood that the box continued to exist, in its same location, after it was occluded by the screen, and (2) expected the screen to stop against the occluded box and were surprised, or puzzled, when it failed to do so. A control experiment in which the box was placed next to the screen provided support for this interpretation of the results. Together, the results of these experiments indicate that, contrary to Piaget’s (1954) claims, infants as young as 5 months of age understand that objects continue to exist when occluded. The results, also indicate that 5-month-old infants realize that solid objects do not move through the space occupied by other solid objects. (shrink)

Concerns about children's ability to fully comprehend and evaluate advertising messages has stimulated substantial research and heated debate among scholars, business leaders, consumer advocates, and public policy makers for more than three decades. During that time, some very fundamental questions about the fairness of marketing to children have been raised, yet many remain unresolved today. With the emergence of increasingly sophisticated advertising media, promotional offers and creative appeals in recent years, new issues have also developed. This paper provides a basis (...) for further examination of some the key questions in this area, and suggests how children's advertising research can be employed to illuminate them. (shrink)

A series of experiments investigated the effect of speakers’ language, accent, and race on children’s social preferences. When presented with photographs and voice recordings of novel children, 5-year-old children chose to be friends with native speakers of their native language rather than foreign-language or foreign-accented speakers. These preferences were not exclusively due to the intelligibility of the speech, as children found the accented speech to be comprehensible, and did not make social distinctions between foreign-accented and foreign-language speakers. Finally, children chose (...) same-race children as friends when the target children were silent, but they chose other-race children with a native accent when accent was pitted against race. A control experiment provided evidence that children’s privileging of accent over race was not due to the relative familiarity of each dimension. The results, discussed in an evolutionary framework, suggest that children preferentially evaluate others along dimensions that distinguished social groups in prehistoric human societies. (shrink)

The astute reviews by Hamlin and by Revencu and Csibra provide compelling arguments and evidence for the early emergence of moral evaluation, communication, and pedagogical learning. I accept these conclusions but not the reviewers' claims that infants' talents in these domains depend on core systems of moral evaluation or pedagogical communication. Instead, I suggest that core knowledge of people as agents and as social beings, together with infants' emerging understanding of their native language, support learning about people as moral agents, (...) moral patients, communicators, and teachers. These issues are open, however, and our competing views invite further testing. (shrink)

Introduction to an issue on moral and scientific realism in honor of Richard N. Boyd and Nicholas L. Sturgeon (Elizabeth S. Radcliffe, guest editor).

ABSTRACT This essay meditates on the entanglement of history and memory with forgetfulness, with silencing, with what is before or outside speech. Recalling along the way a few of the manifold varieties of the unthinkable made manifest in recent events, it notes the same mute iteration that led Freud to the death drive, only to be troubled once again by the very same repetitions enfolded in the diagnosis of cultural malaise Freud built upon his insight. Turning to Georg Simmel’s Philosophy (...) of Money for an alternative, non-psychoanalytic account of unconscious purpose as a trans-individual, cultural phenomenon, it arrives once again at the hypertrophic life-technologies of the modern—and at Simmel’s account of money as the ultimate being without qualities, “the most extreme … configuration of Geist” itself, which so thoroughly underpins ways of living that, obscuring dimensions of value that cannot be quantified, silently hum on in the face of catastrophe. (shrink)

in a recent article entitled “Hume on the Passions,” Stephen Buckle opens with the claim that Hume’s theory of the passions has largely been neglected. “Apart from a couple of famous sections in the Treatise concerning the sources of action,” he writes, “the subject matter has rarely excited interest.”1 His analysis of why the subject of the passions in Hume has been uninspiring points to the fact that readers have largely misunderstood the point of Hume’s theory. They usually regard the (...) account as yet another mechanistic analysis of the passions in the vein of seventeenth-century science, alongside the offerings of Malebranche, Hobbes, and Spinoza. Buckle is right to point out that there is a.. (shrink)

On a standard interpretation, Hume argued that reason is not practical, because its operations are limited to “demonstration” and “probability.” But recent critics claim that by limiting reason’s operations to only these two, his argument begs the question. Despite this, a better argument for motivational skepticism can be found in Hume’s text, one that emphasizes reason’s inability to generate motive force against contrary desires or passions. Nothing can oppose an impulse but a contrary impulse, Hume believed, and reason cannot generate (...) an impulse. This better argument is here developed and defended. Two lines of objection to it can be anticipated: that reason actually can generate impulsive force, based on contents of its normative judgments and that reason neither can nor needs to generate an impulse, since the actions of rational agents are not determined by forceful impulses of desire, as Hume supposed. These objections are answered by pointing out their unsatisfying consequences. (shrink)

What leads humans to divide the social world into groups, preferring their own group and disfavoring others? Experiments with infants and young children suggest these tendencies are based on predispo- sitions that emerge early in life and depend, in part, on natural language. Young infants prefer to look at a person who previously spoke their native language. Older infants preferentially accept toys from native-language speakers, and preschool children preferentially select native-language speakers as friends. Variations in accent are sufficient to evoke (...) these social preferences, which are observed in infants before they produce or comprehend speech and are exhibited by children even when they comprehend the foreign-accented speech. Early-developing preferences for native-language speakers may serve as a foundation for later-developing preferences and conflicts among social groups. (shrink)

Successful research of Caribbean signed languages and deaf communities involves negotiating complex communication ethics toward both people and languages. In this article, I ground a call for ethical listening to Caribbean deaf and signing communities in sociolinguistic research that investigated deaf community and sign language boundaries in the Caribbean. I argue that a dialogic ethic that privileges listening is foundational for ethical research with Caribbean deaf and signing communities by discussing two ethical challenges that were central to understanding their narrative (...) ground: the communicative construction of categories of linguistic membership and advocacy of social justice and human rights. (shrink)

ABSTRACT Perpetuation of privileged norming in organizations threatens the fragile hope that the theory and practice of professionalism can evolve alongside commitments to equity and inclusion. Uncritical engagement with a normative professionalism can lead to the muting of differences and strengths that diverse standpoints offer to professional communities. We look to the field of Medicine as an example for other professional groups, in which experts have criticized its development of a normative professionalism shaped by, retaining, and sustaining privilege. Using a (...) triad of case studies and co-cultural theory, we suggest that non-dominant perspectives and behaviors ought to be better recognized and welcomed as part of professionalism discourse, and that professional education ought to include co-cultural awareness of communication behaviors and their function as identity performance. We suggest that recognizing and reinforcing accommodation behaviors will lead to a more robust inclusivity for an evolving normativity, and that the wisdom habits of curiosity, perspective, love of learning, judgment, and creativity must be brought to bear on improving co-cultural dialogue, dismantling systemic privilege, practicing attributional complexity, and building genuinely dialogic professional communities rather than depersonalized collectives. (shrink)

That Hume 's theory can be interpreted in two widely divergent ways-as a version of sentimentalism and as an ideal observer theory-is symptomatic of a puzzle ensconced in Hume 's theory. How can the ground of morality be internal and motivating when an inference to the feelings of a spectator in "the general point of view" is typically necessary to get to genuine moral distinctions? This paper considers and rejects the suggestion that in moral education, for Hume, the inculcation of (...) morality internalizes the sentiments of the ideal observer. It ultimately offers a different resolution of the conflicting strains. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Editors’ IntroductionElizabeth S. Radcliffe and Mark G. SpencerThis issue opens with the winning essay in the Second Annual Hume Studies Essay Prize competition: “Hume’s Passion-Based Account of Moral Responsibility,” by Taro Okamura. Dr. Okamura’s essay was chosen as the 2022 winner from among papers submitted by emerging scholars from August 2021 through July 2022. Dr. Okamura received his Ph.D. from the University of Alberta in 2022. He is currently (...) a Japan Society for the Promotion of Science Research Fellow at the Graduate School of Humanities and Sociology at the University of Tokyo.The competition for the Third Prize closed on August 1, 2023, and the winner will be announced in our next issue. Please see the Call for Papers for the fourth competition in the back of this issue. The competition is open to authors ten or fewer years from the Ph.D.A special aspect of our current issue is its spotlight on Hume’s Essays, Moral, Political, and Literary. Renowned Dutch Enlightenment scholar, Frederic L. van Holthoon, presents his analysis of some of Hume’s essays, which he argues constitute Hume’s project of writing on political, or public, issues—a goal he did not get to complete with the Treatise. Also, established Hume scholar Lorne Falkenstein offers an extended review of the newly published Clarendon edition of Hume’s essays, in two volumes (edited by Tom L. Beauchamp and Mark A. Box, with Michael Silverthorne, J. A. W. Gunn, and F. David Harvey).Finally, we want to bring to the attention of our readers that, in fewer than two years, Hume Studies will be marking the 50th anniversary of its first publication. For this event, we are planning a special jubilee issue, 50:1 (April 2025). We hope to include among the unique features of that issue paragraphs or statements from our readers in answer to this query: “Of all of the articles that have been published in Hume Studies over the past 50 years, which one is most noteworthy to you? Why so?” Please see the “Call for Entries” in the back of this issue and on the Hume Studies website. We invite your responses! [End Page 193]Copyright © 2023 Hume Studies... (shrink)

What happens when adjudication signals its own artifice? Or when jurisprudence is animated by what Maksymilian Del Mar calls ‘legal artifacts’ that invite us to suspend certain of our prevailing no...